具体描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用户评价
##挺好看的，实效性很强，跟covid联系很紧密。最喜欢看这种众人拾柴火焰高，每个人的研究都为某个成功的发现奠定基石的故事。所以其实叫code breakers确实更合适，很喜欢Doudna和Charpentier这种微妙的情感，既是合作者又有点小竞争的感觉。中间有段讲gene editing的好处和坏处觉得有点离题，好在后面又拉回来了
评分##真是一本一言难尽的书，有点不伦不类的。如果是个传记，那么这是我读过的最失败的传记了，读之前对女主充满了崇拜，读完了几乎好感全无，觉得她好胜心过强。这本书是开始介绍珍妮弗·道德纳的背景求学经历以及如何开始研究RNA ，然后变成了一本CRISPR 科普，又陆续介绍了一群对CRISPR有贡献的科学家，然后开始八卦道德纳和张的CRISPR 专利战，然后又开始讨论基因改造的道德性，然后聊了聊RNA和新冠，最后以得诺贝尔奖结束。其实与其写成传记，不如学成一部纪实文学，从各方面客观的去讲述基因改造的发展更好一些。 让我想八卦的地方是，作者至少在2019年就开始参加一些活动了，应该是在最迟2019就开始着手这本书，那么后来的诺贝尔和新冠只是巧合的话，作者也太好运了。
评分##科普的部分已经在其它书里见过了，传记的部分又不是很有意思。
评分##我并不很喜欢沃尔特.艾萨克森，以前看过其乔布斯传（中文），达芬奇传（有声书），总的来说，中规中矩。 然就本书而言，通过传记故事的方式，学到很多生化知识，体验象牙塔里的科研生活，还是很有收获。 最难忘怀的情节是他对Watson和其儿子的访问，可惜太短，毕竟是枝节。 人物传记，尽管是著名人物，要写出史诗感，张力十足也不容易。
评分##roadtrip上听完了有声书 比预计的更有意思更drama crispr出来的时候 很多报道podcast采访 biotech/genes也hype很久了 但都知道了些皮毛 这本书听完才觉得真的懂了些 science确实是很competitive的field 特别是这些lab类的 发文章cycle还算快 就真的是分秒必争 同事之间的合作和竞争关系微妙 好奇如果有本从boston角度来讲(vs. Berkeley)会是怎么个态度 Isaacson很是细节之王 多少年前的事情 估计当事人都记不清楚了 他能写细致至极 feminism贯穿了整本书 最后几章讲gene editing moral的有点散
评分##平平无奇 你好我好大家好
评分##roadtrip上听完了有声书 比预计的更有意思更drama crispr出来的时候 很多报道podcast采访 biotech/genes也hype很久了 但都知道了些皮毛 这本书听完才觉得真的懂了些 science确实是很competitive的field 特别是这些lab类的 发文章cycle还算快 就真的是分秒必争 同事之间的合作和竞争关系微妙 好奇如果有本从boston角度来讲(vs. Berkeley)会是怎么个态度 Isaacson很是细节之王 多少年前的事情 估计当事人都记不清楚了 他能写细致至极 feminism贯穿了整本书 最后几章讲gene editing moral的有点散
评分##作为对科技新闻有一定关注的读者，我是觉得传记大拿的这本新书略略有点水、有点散呀……可能书中纪事我多少有些了解，所以读来新鲜感不强。而厚厚近600页感觉有点四不像——既不是传记、也不是新闻调查；有点像在翻资料汇编，又有点像在刷公众号。 不过也不难看。最留下印象的几点： ➊用生物学词汇mosaic来形容人性的复杂多面向，a better description than grayscale； ➋第一次了解到biohackers（书中以Josiah Zayner为代表）这个群体。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授关于“playing god”的论述； ➍D与C两位女科学家渐行渐远（不是闹翻）的友谊（研究合作与私交两个层面）。
评分##读了Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者写到science内容一笔带过，想了解详细内容自己去看文献，历史的部分讲述得比较精彩，不搞学术的人读了能看到研究进步发展时间线上科学家们的主导、参与、被遗忘、被放弃及存活的真实展现，good read
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