The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
##挺好看的,实效性很强,跟covid联系很紧密。最喜欢看这种众人拾柴火焰高,每个人的研究都为某个成功的发现奠定基石的故事。所以其实叫code breakers确实更合适,很喜欢Doudna和Charpentier这种微妙的情感,既是合作者又有点小竞争的感觉。中间有段讲gene editing的好处和坏处觉得有点离题,好在后面又拉回来了
评分##很精彩的故事,高尖端的科技,科学家的争名夺利,关于道德的争论,都很有意思,不过感觉作者夹带私货略多
评分##很好的了解CRISP的科普
评分##其实应该叫The Code Breakers,除了Doudna and Charpentier, 作者对Zhang Feng的评价也很高,作者一直在强调对于基础科学研究的重要性,在十四五计划也有强调,期待各国能加大科研投入for a greater good
评分##感觉看了一部宫斗剧?
评分##很好的了解CRISP的科普
评分##我并不很喜欢沃尔特.艾萨克森,以前看过其乔布斯传(中文),达芬奇传(有声书),总的来说,中规中矩。 然就本书而言,通过传记故事的方式,学到很多生化知识,体验象牙塔里的科研生活,还是很有收获。 最难忘怀的情节是他对Watson和其儿子的访问,可惜太短,毕竟是枝节。 人物传记,尽管是著名人物,要写出史诗感,张力十足也不容易。
评分##最多3.5星吧。与其说这是一本传记不如说是科普。然而作者写科普书的能力远不如其他专业学者。 关于基因编辑的道德问题作者花了很长的篇幅讨论,这个话题写几本书都可以,作者在这方面的理论知识显然还不够。道德问题谁都有权利发言,但写太多了看着很乏味。 零星的点:金字塔尖的竞争很激烈,人尖们犯过的错走过的弯路有借鉴意义,国外的前沿科学研究值得时刻跟进和关注。
评分##读了Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分,作者写到science内容一笔带过,想了解详细内容自己去看文献,历史的部分讲述得比较精彩,不搞学术的人读了能看到研究进步发展时间线上科学家们的主导、参与、被遗忘、被放弃及存活的真实展现,good read
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